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Articles from Thomas Schmitt | Selfgrowth.com
- What Are PEGs? - by Submitted on Aug 18, 2021 from Thomas SchmittPEGs (polyethylene glycols) are composed of polyether compounds repeating ethylene glycol units according to the constituent monomer or parent molecule (as ethylene glycol, ethylene oxide, or oxyethylene). Most PEGs are commonly available commercially as mixtures of different oligomer sizes in ...
Views: 523 - The Synthesis of Nanoparticles You Don't Want to Miss - by Submitted on Nov 01, 2021 from Thomas SchmittNanoparticle synthesis refers to methods for creating nanoparticles. Nanoparticles can be derived from larger molecules, or synthesized by ‘bottom-up’ methods that, for example, nucleate and grow particles from fine molecular distributions in liquid or vapour phase. Synthesis can also include ...
Views: 522 - What Are Melamine Resin Particles? - by Submitted on May 24, 2022 from Thomas SchmittMelamine (1, 3, 5-triamino-2, 4, 6-triazine) resin, or melamine formaldehyde (MF) is one of the hardest and stiffest thermosetting polymers, which provides good properties and performance. It is an amino resin and has various material advantages, such as transparency, better hardness, thermal ...
Views: 514 - A Quick Review of Cell Isolation & Organelles Isolation - by Submitted on Sep 22, 2021 from Thomas SchmittWhat is organelles isolation? The separation of organelles is achieved by cell membrane lysis and density gradient centrifugation to separate organelles from contaminated cell structures. The intact nucleus and organelles have a unique size in mammalian cells, allowing them to be separated by ...
Views: 507 - What is Antibody KD - by Submitted on Jul 23, 2021 from Thomas SchmittIn chemistry, biochemistry, and pharmacology, the dissociation constant (KD) is a specific type of equilibrium constant used to measure the tendency of larger objects to reversibly separate (dissociate) into smaller components, such as When the complex decomposes into its component molecules or ...
Views: 503 - Neuropilin-1 Promotes SARS-CoV-2 Entry into Host Cells - by Submitted on Apr 01, 2021 from Thomas SchmittThe 2019 Coronavirus Disease (COVID-19) caused by the new coronavirus SARS-CoV-2 is now raging around the world. Existing studies have shown that SARS-CoV-2 infects host cells through the receptor ACE2. In a new study, scientists discovered that neuropilin 1 (NRP1) is a factor that can promote ...
Views: 498 - Researchers Learn That Non-toxic Concentration of Silver Nanoparticles Can Antagonize Arsenic-induced Genotoxicity - by Submitted on Apr 01, 2021 from Thomas SchmittRecently, a research team found that non-toxic concentrations of silver nanoparticles can antagonize the genotoxicity induced by arsenic by reducing the bioaccumulation of heavy metal arsenic in mammalian cells and enhancing the anti-oxidant ability in the cells. Related research results were ...
Views: 498 - What Are D-Glucosamines? - by Submitted on May 24, 2022 from Thomas SchmittGlucosamine is a natural component of cartilage and is widely used as an over-the-counter nutritional supplement to reduce the pain and cartilage loss of osteoarthritis. Glucosamine is usually taken in combination with chondroitin, which is a glycosaminoglycan that also exists in ...
Views: 498 - What Are Nano Secondary Antibodies - by Submitted on Sep 22, 2021 from Thomas SchmittAntibodies are biological protein molecules that are produced by immune B cells after being stimulated by antigens that can specifically bind to the antigen, and then neutralize the antigen. Because antibodies can specifically bind antigens with high affinity, antibodies have always been one of ...
Views: 493 - What Are D-Glucosamines? - by Submitted on Jun 13, 2022 from Thomas SchmittGlucosamine is a natural component of cartilage and is widely used as an over-the-counter nutritional supplement to reduce the pain and cartilage loss of osteoarthritis. Glucosamine is usually taken in combination with chondroitin, which is a glycosaminoglycan that also exists in ...
Views: 491 - Application of Polyethylene Glycol (PEG) in the Medical Field - by Submitted on Jan 27, 2022 from Thomas SchmittThe chemical structure of polyethylene glycol (PEG) is HO-(CH2CH2)n-OH, which is a general term for ethylene glycol polymers with a relative molecular mass of 200 to 8000 and above. Polyethylene glycol is the polymer with the lowest level of absorption by proteins and cells among the known ...
Views: 490 - Chemical Medicine Lung Inhalation Nano Preparation - by Submitted on Dec 02, 2021 from Thomas SchmittAt present, a variety of chemical drugs are combined with nano-carriers to make lung-inhaled nano-preparations, and have achieved good results, such as anti-tuberculosis drugs, itraconazole, terbutaline sulfate, ciprofloxacin, curcumin and Camptothecin. Anti-tuberculosis drugs Polylactic ...
Views: 490 - Liposomes for DNA/RNA Delivery - by Submitted on Jun 24, 2021 from Thomas SchmittLiposomes are vesicular structures, and the unique advantages imparted by lipid vesicles are their diverse range of morphologies, compositions, abilities to envelope and protect many types of therapeutic biomolecules, lack of immunogenic response, low cost, and their differential release ...
Views: 490 - What is Nano Dressing? - by Submitted on Oct 30, 2023 from Thomas SchmittNanotechnology has not only received attention and applications in the field of drug delivery, but also has achieved many successes in the field of tissue engineering. Nano dressings can be defined as dressings in which nanomaterials are the matrix. The birth of nano dressings has brought new ...
Views: 489 - What Is Chitosan? - by Submitted on Apr 23, 2021 from Thomas SchmittChitosan is the second most abundant biopolymer in the world, only less than cellulose. It is a versatile biopolymer with unique properties, and is nontoxic, biodegradable and biocompatible. Chitosan is discovered by Rouget in 1859, when the chitin was treated with hot potassium hydroxide ...
Views: 482 - What are Strongyloides? - by Submitted on May 24, 2022 from Thomas SchmittStrongyloides is an opportunistic pathogenic parasitic nematode. Adults parasitize in the small intestine of cats, dogs and humans. The larvae can invade lung, brain, liver, kidney and other tissues and organs, causing strongyloidiasis. The disease is mainly prevalent in warm and humid tropical ...
Views: 480 - What Are PMMA Micro- and Nanoparticles? - by Submitted on Oct 30, 2023 from Thomas SchmittPoly(methyl methacrylate) (PMMA) micro- and nanoparticles are highly spherical, optically clear, and can be dissolved with solvents. These PMMA particles are hydrophilic, transparent, amorphous and colorless thermoplastics that are featured with excellent UV resistance. What is PMMA used ...
Views: 479 - The Switch to Burn Fat-IL-27 - by Submitted on Mar 23, 2022 from Thomas SchmittObesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Excessive food intake or changes in the body’s metabolism lead to excessive accumulation of fat in the body, resulting in ...
Views: 476 - What Role Does Gold Nanorod Play in Cancer Treatment? - by Submitted on Jun 01, 2021 from Thomas SchmittGold nanorods (AuNRs) are gold nanoparticles with a specific morphology in the range of 1 to 100 nm. They present two distinct SPRs on the transversal axis and the longitudinal axis. Longitudinal plasmon resonance can provide absorption of wavelength radiation in the near-infrared region (NIR), ...
Views: 476 - Why does Immunotherapy Have No Effect on Certain Tumors - by Submitted on Jun 01, 2021 from Thomas SchmittAs we all know, tumor tissue is not only composed of cancer cells, it also contains other types of cells. These other cell types can affect tumor behavior and have a profound impact on whether the tumor will respond to therapy, including immunity therapy etc. Fibroblasts are distributed ...
Views: 476 - What are Metal Nanoclusters - by Submitted on Jan 27, 2022 from Thomas SchmittMetal nanoclusters are a kind of nanomaterials with a size of less than 2 nm and stacked by 1 to 150 metal atoms. Metal nanoclusters have a typical core-shell structure, consisting of a metal atomic core and a ligand molecular shell. Ligands are usually substances that have strong covalent ...
Views: 475 - What are AMOTs? - by Submitted on May 08, 2023 from Thomas SchmittAMOT family, also known as the Motin family, has three members: angiomotin (AMOT), angiomotin-like protein 1 (AMOTL1), and angiomotin-like protein 2 (AMOTL2). There are two shear isomers of AMOT, AMOT-P130 and AMOT-P80. AMOT was first discovered and named in 2001. Existing studies have shown ...
Views: 474 - What Are Gold Nanorods? - by Submitted on Jan 05, 2022 from Thomas SchmittGold nanorods, as a kind of capsule-like gold nanoparticles with a scale from a few nanometers to hundreds of nanometers, have more peculiar optical properties than spherical gold nanoparticles due to their localized surface plasmon resonance (LSPR) effect. Gold nanorods are biomaterials ...
Views: 473 - Application of 3D Printing Bioinks Tissue Repair and Regenerative Medicine - by Submitted on Dec 26, 2023 from Thomas SchmittIntroduction to 3D Printing In the 1980s, American engineer Charles Hull developed rapid prototyping technology by combining points and surfaces and then using light reinforcement. After numerous failures, he finally invented stereolithography technology. Based on this technology, the world’s ...
Views: 471 - Type 1 Diabetes Autoantibody Research - by Submitted on Oct 30, 2023 from Thomas SchmittType 1 diabetes (T1DM) is an autoimmune disease caused by the destruction of beta cells first, leading to the destruction of related pancreatic islet function. In patients with this disease, generally their humoral immunity and cellular immunity cannot work normally. Humoral immunity is ...
Views: 471 - Application Research of Natural Hirudin - by Submitted on Mar 23, 2022 from Thomas SchmittHirudin is one of the most significant and most studied active ingredients in leeches and their salivary glands. It is a small molecule protein (polypeptide). Leeches are rich in hirudin, which has a strong inhibitory effect on thrombin and is the strongest natural specific inhibitor of thrombin ...
Views: 467 - Gold Nanoparticles in Medicine: A Tiny Marvel with Big Potential - by Submitted on Nov 27, 2023 from Thomas SchmittWith the continuous development of nanotechnology, gold nanoparticles are widely used in the field of medicine. Gold nanoparticles not only have good controllability, biocompatibility, and biosorption, but also have a high degree of stability, and can achieve specific biometrics and functions ...
Views: 467 - Overview of Brucella Abortus - by Submitted on Oct 31, 2022 from Thomas SchmittBrucellosis is a zoonotic infectious disease caused by Brucella, and it is one of the most widespread zoonotic diseases in the world, which brings great losses to the animal husbandry industry. Here, we will outline several aspects about the pathogen, living environment, identification, and ...
Views: 466 - What Are Contrast Agents for Computed Tomography? - by Submitted on Aug 24, 2022 from Thomas SchmittComputed tomography, or CT, was developed in 1960s and early 1970s. It refers to a computerized X-ray imaging procedure in which a narrow beam of X-rays is aimed at the patient and rapidly revolves around the body, producing signals that are processed by a machine computer to generate a ...
Views: 466 - EXO-CD24 and the Treatment of COVID-19 - by Submitted on Dec 01, 2021 from Thomas SchmittOne of the characteristics that cancer cells can obtain and maintain in the body is their ability to evade detection and destruction by the human immune system. For example, some tumor cells produce higher-than-normal amounts of protein as a “don’t eat me” signal, which exists on the cell ...
Views: 464 - Quantum Dots Technology in Fluorescent Labeling - by Submitted on Jul 23, 2021 from Thomas SchmittLiposomes are vesicular structures, and the unique advantages imparted by lipid vesicles are their diverse range of morphologies, compositions, abilities to envelope and protect many types of therapeutic biomolecules, lack of immunogenic response, low cost, and their differential release ...
Views: 464 - Research on Capsular Polysaccharide Protein Conjugate Vaccine of Streptococcus Pneumoniae - by Submitted on Nov 27, 2023 from Thomas SchmittStreptococcus pneumoniae is a class of Gram-positive pathogenic bacteria that was first isolated in 1881. The chemical composition of the mucus layer on the surface of Streptococcus pneumoniae is a polysaccharide capsule, which is the main pathogenic substance of Streptococcus pneumoniae and has ...
Views: 460 - What Is Polylactide? - by Submitted on Aug 18, 2023 from Thomas SchmittPolylactide (PLA), also the polylactic acid, is the biodegradable hydrolyzable aliphatic semicrystalline polyester that can be produced through the direct condensation reaction of its monomer, lactic acid, as the oligomer, and also by a ring-opening polymerization of the cyclic lactide ...
Views: 460 - A Few Tips To Better Know About Neutral Lipids - by Submitted on Jan 05, 2022 from Thomas SchmittWhat Are Neutral Lipids? Neutral lipids are defined as hydrophobic molecules lacking charged groups. Neutral lipids, such as cholesteryl ester (CE), triacylglycerol (TAG), and wax ester (WE), provide organisms with inert forms of energy used in conditions of nutrient deprivation and ...
Views: 459 - What Are Dextrans? - by Submitted on Feb 28, 2022 from Thomas SchmittDextran is a polysaccharide comprised of d-glucopyranose (d-glucose) repeating units linked through glycosidic linkages. It is biocompatible, biodegradable, and presents antithrombotic and anti-inflammatory properties. Dextran functional hydroxyl (–OH) groups offer an easy point for chemical ...
Views: 459 - Nipah Virus Detection Method - by Submitted on Apr 15, 2022 from Thomas SchmittOver the past few decades, there have been multiple outbreaks of viruses causing severe and severe disease around the world, including known and unknown viral pathogens such as SARS-CoV, Ebola, Lassa fever, Marburg virus, Nipah virus, Hendra virus, Rift Valley fever virus and Middle East ...
Views: 458 - A Review of Proteolytic Targeting Chimeras - by Submitted on Apr 03, 2023 from Thomas SchmittThe concept of proteolytic targeting chimera (PROTAC) was first proposed by Crews and Deshaies laboratory in 2001, the team successfully achieved the degradation of methionyl aminopeptidase 2 (MetAp-2) by PROTAC method. Since then, PROTACs targeting androgen receptor (AR) and estrogen receptor ...
Views: 457 - The New Mechanism of Aging To Promote Cancer - by Submitted on Apr 23, 2021 from Thomas SchmittAs we age, the body will accumulate “garbage” in the body during the process of converting food into energy. Clinical statistics have found that the risk of cancer and related mortality in humans increases significantly with age from the age of 65. Is it because the body’s “junk” substances ...
Views: 456 - What Are The Influencing Factors of Drug Percutaneous Absorption - by Submitted on Jun 24, 2021 from Thomas SchmittIn the clinical transdermal drug delivery process, there are many factors that affect the transdermal absorption of the drug, mainly including: skin hydration, skin temperature, skin conditions, and skin locations. Skin Hydration The phenomenon that the water content of the skin exceeds the ...
Views: 456 - What Are Gold NanoCages? - by Submitted on Dec 27, 2022 from Thomas SchmittGold nanocages refer to the hollow gold nanostructures with porous walls that were developed by Sun and Xia and Chen et al. in the early 2000s. The hollow and porous structures are synthesized by the galvanic replacement between silver nanocubes and chloroauric acid in aqueous solution. By ...
Views: 454 - What Are Iron Oxide Nanoparticles? - by Submitted on Oct 31, 2022 from Thomas SchmittIron oxides are common compounds, which are widespread in nature and can be readily synthesized in the laboratory. Iron oxide nanoparticles (NPs) typically refer to the materials that consist of magnetite (Fe3O4) or maghemite (γ-Fe2O3) and have a size ranging from 1 to 100 nm. These ...
Views: 454 - Progress in the Development of Targeted Anti-Tumor Antibody-Drug Conjugates - by Submitted on Mar 27, 2024 from Thomas SchmittAntibody-drug conjugates (ADCs) are conjugated products of monoclonal antibodies (mAbs) and cytotoxic small molecules. In tumor treatment, although monoclonal antibodies have good targeting properties, most of them target extracellular or cell surface antigens, have weak anti-tumor activity, ...
Views: 452 - Cancer Target: Mesothelin - by Submitted on Feb 01, 2023 from Thomas SchmittMesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. Its biological function has not yet been clarified, but due to its limited distribution in normal tissues and high expression in some tumor tissues, it is expected to be used in tumor-specific treatment. In ...
Views: 451 - Difficulties in Research and Development of the Novel Coronavirus Vaccine - by Submitted on Feb 04, 2021 from Thomas SchmittAt present, the outbreak of COVID-19 has spread to more than 200 countries and regions around the world, and the number of confirmed cases has exceeded 6 million. The world is racing to develop the Novel Coronavirus vaccine. Dozens of candidate vaccines are undergoing pre-clinical evaluation, ...
Views: 451 - Overview of Monkeypox - by Submitted on Aug 24, 2022 from Thomas SchmittMonkeypox is caused by the monkeypox virus. Monkeypox virus is a virus belonging to the genus Orthopoxvirus of the Poxviridae family. Monkeypox virus has the typical shape of Orthopox virus, with a rounded brick shape or an oval shape and a size of 200-400 nm. The virus is enveloped by a ...
Views: 451 - Sucrose Polymer Overview - by Submitted on Jul 20, 2022 from Thomas SchmittSucrose is a disaccharide with a unique structure. It is a non-reducing sugar formed by removing a molecule of water from the glycoside hydroxyl group of a molecule of α-D-(+)-glucopyranose and a molecule of β-D-(-)-fructofuranose. During the hydrolysis process, the specific optical rotation of ...
Views: 451 - The Role of CXCR5/CXCL13 Axis in Tumors - by Submitted on Dec 26, 2023 from Thomas SchmittThe tumor microenvironment is composed of tumor cells and non-tumor cells (including fibroblasts, vascular and lymphatic endothelial cells, various immune cells) and extracellular components (such as extracellular matrix, cytokines, inflammatory factors, chemokines, etc.) in tumor tissues. ...
Views: 450 - What Are Phosphate Magnetic Particles? - by Submitted on Apr 03, 2023 from Thomas SchmittPhosphonates or phosphonic acids are organic compounds containing C–PO(OH)2 or C–PO(OR)2 groups (where R = alkyl, aryl). Most phosphonates are highly water-soluble, while phosphonic acids are only sparingly soluble. Phosphonates are not volatile and are poorly soluble in organic solvents. ...
Views: 449 - Carrageenans as a Versatile Tool in Drug Delivery - by Submitted on May 08, 2023 from Thomas SchmittDrug delivery is the process of administering pharmaceutical substances to targeted areas in the body. It plays a vital role in the effective treatment of various diseases. However, drug delivery is often challenged by the body’s natural defenses, such as the gastrointestinal tract and the ...
Views: 447 - Exploring Dyed Polystyrene Latex Particles Enhancing Immunoassays and Beyond - by Submitted on Mar 27, 2024 from Thomas SchmittWhat are Dyed Polystyrene Latex Particles? Polystyrene particles (PSP) are commercially available in different sizes, ranging from 15 nanometers to several micrometers, with narrow size distributions and various surface chemistries. Additionally, polystyrene is generally considered inert and ...
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